| Year | Title | Role | Notes |
| 1996 | In the House | Female Basketball Player (uncredited) | Episode: "Hoop Screams". |
| 1997 | Coach | (uncredited) | Episode: "It's A Swamp Thing". |
| 2001–02 | The Way We Do It | Various | |
| 2004 | Girlfriends | Mabel | Episode: "Love, Peace and Hair Grease". Credited as Leslie. |
| 2007 | Mind of Mencia | Nurse Brownsugar/Bodyguard | 2 episodes |
| American Body Shop | Roshanda Washington | Episode: "Fluids" |
| 2010 | Chelsea Lately | Herself (roundtable panelist) | Episode: "Crispin Glover" |
| Problem Child: Leslie Jones (aka Big Les: Problem Child) | Herself | Showtime stand-up comedy special |
| 2012 | Daddy Knows Best | Angry Woman | Episode: "Taser" |
| 2013 | Sullivan & Son | Bobbie | Episode: "Acceptance" |
| See Dad Run | Security Guard | Episode: "See Dad Be Normal...ish" |
| The League | Stand Up Student | Episode: "The Bringer Show" |
| 2014 | Workaholics | Lynette | Episode: "The One Where the Guys Play Basketball and Do the Friends Title Thing" |
| 2014–19 | Saturday Night Live | Herself / Various | Cast member and writerNominated – Primetime Emmy Award for Outstanding Original Music and Lyrics (2019)Nominated – Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series (2017, 2018)Nominated – Writers Guild of America Award for Outstanding Writing in a Comedy/Variety Series (2015) |
| 2015 | The Awesomes | Silent But Deadly | Voice, episode: "The Final Showdown" |
| 2016 | The Blacklist | Citizen | Episode: "Lady Ambrosia" |
| 2017–19 | The $100,000 Pyramid | Herself | 3 episodes |
| 2018 | Kevin (Probably) Saves the World | Cindy | Episode: "The Right Thing" |
| 2020 | Supermarket Sweep | Host | |
| RuPaul's Drag Race | Herself | Episode: "The Ball Ball" |
| Death to 2020 | Dr. Maggie Gravel | Television special |
| Leslie Jones: Time Machine | Herself | Netflix special |
| 2021 | Celebrity Wheel of Fortune | Episode: "Leslie Jones, Chandra Wilson and Tony Hawk" |
| 2021 MTV Movie & TV Awards | Host | Television special |
| Last Week Tonight with John Oliver | Herself | Episode: "Hair" |
| 2022 | Out of Office | Ally | Television film |
| 2022–23 | Our Flag Means Death | Spanish Jackie | Recurring role |
| 2023 | BMF | SAC Tracy Chambers | 2 episodes |
| Hit-Monkey | Eunice | Voice |
| 2023–2024 | The Daily Show | Herself | Guest host: 7 episodes (Jan. 17–19, Nov. 13–16)Guest appearance: 1 episode (Mar. 28) |
| 2025 | American Dad! | Coach (voice) | Episode: "The Mystery of the Missing Bazooka Shark Babe" |
| Phineas and Ferb | Alliance Commander (voice) | Episode: "Meap Me in St. Louis" |
| DMV | Sally | Episode: "The Next Window" |
